Can a stable size distribution alone establish shelf life?
No. Size is one observation. Evaluate interaction conditions and the relevant changes over time before interpreting the formulation's physical stability.
A formulation change may alter interactions before a large size change becomes visible, while physical separation can occur for reasons not resolved by charge alone. Plan complementary measurements around the product and the time-dependent behavior being studied. Microtrac NANOTRAC, STABINO ZETA and TURBISCAN workflows address different parts of that investigation.
How can charge, size and separation be followed together?
Use matched portions of the same formulations. Record charge response with STABINO ZETA, particle-size changes with a suitable NANOTRAC or SYNC configuration, and physical separation over time with TURBISCAN. Align the formulation, elapsed time and storage conditions across the observations.
Method details to record
| Consideration | What to record |
|---|---|
| Formulation context | Composition and liquid environment |
| Measurement set | Size, charge and physical stability |
| Comparison design | Time and controlled formulation changes |
How should an early charge shift be interpreted?
Check whether a size change or separation appears later under the same storage conditions. The time sequence can guide investigation of the formulation while leaving the product’s shelf-life criterion to its defined stability study.
Explore particle characterization equipment
Review the equipment details and discuss the supported configuration for your sample.