Zellwerk GmbH supplies customized implant blanks from Sponceram® and other materials for research use. Blanks for medical use are in preparation. Implant blanks are easily colonized in our Z® RP Bioreactor equipped with implant-specific holding fixtures. E. g. is a moulded carrier of Sponceram® HA covered by primary chondrocytes embedded in their own collagen matrix. Under appropriate cultivation conditions these chondrocytes express Collagene II and Glucosamine Glucanes in physiological ratios indicating in vivo-like differentiation. Implant blanks made from Sponceram® are ideally suited to generate bone-like structures after colonisation with osteoblasts which calcificate even without addition of specific growth factors.