Routine small samples, flexible vessels and documented mechanochemistry methods.
Useful quantity: 2 × 20 mL · Maximum feed reference: 8 mm
MIXER MILL SYSTEMS
Small samples.
A world of possibilities.
Grind, mix and homogenize with high-frequency impact and friction. Compare five systems for everyday sample preparation, parallel batches, ultrafine wet grinding and temperature-sensitive work.
Not sure which option fits your work?Use the practical selection helper ↗
A PRACTICAL SELECTION HELPER
Find a practical starting point.
Choose the method first, then compare useful quantity per jar and the required number of full-size jar positions. Vial adapters can change sample counts and must be specified separately.
All options in this helper (5)
Six grinding positions for parallel preparation and compatible reaction-vial workflows.
Useful quantity: 6 × 20 mL · Maximum feed reference: 8 mm
High-energy wet grinding and larger screw-lock jars for ultrafine research methods.
Useful quantity: 2 × 45 mL · Maximum feed reference: 10 mm
Automatic liquid-nitrogen cooling for difficult elastic or temperature-sensitive materials.
Useful quantity: 1 × 20 mL · Maximum feed reference: 8 mm
Thermal plates with an external temperature-control setup; optional cryoPad for nitrogen operation.
Useful quantity: 2 × 45 mL · Maximum feed reference: 10 mm
START WITH THE TASK
What does your sample need?
The right system depends on sample quantity, vessel format, target fineness and how temperature should be managed.
MM 400
Routine flexibility
Two-station preparation, bead beating and small research samples.
ExploreMM 500 vario
More samples per run
Six grinding stations and adapters for larger queues of small samples.
ExploreMM 500 nano
Ultrafine wet grinding
High-energy preparation with larger jars and a route to nano-scale particles.
ExploreCryoMill
Automatic cryogenic cooling
Continuous nitrogen cooling for elastic or temperature-sensitive samples.
ExploreMM 500 control
Heating & cooling control
Thermal plates with an external tempering source for monitored methods.
ExploreEXPLORE THE RANGE
Five systems.
Five clear priorities.
Select a product for its operating principle, useful sample quantities, compatible accessories and detailed specifications.
THE VERSATILE STARTING POINT
MM 400
Routine preparation & flexible small samples. Manual pre-cooling with compatible steel jars.
- Grinding stations
- 2
- Frequency
- 3–30 Hz
- Sample quantity*
- 2 × 20 ml
- Final fineness*
- ~ 5 µm
MORE SAMPLES IN EACH RUN
MM 500 vario
Parallel batches & biological sample throughput. Manual pre-cooling with compatible steel jars.
- Grinding stations
- 6
- Frequency
- 3–35 Hz
- Sample quantity*
- 6 × 20 ml
- Final fineness*
- ~ 5 µm
HIGH ENERGY. FINER POSSIBILITIES.
MM 500 nano
Ultrafine wet grinding & high-energy research. Manual pre-cooling; no integrated thermal plates.
- Grinding stations
- 2
- Frequency
- 3–35 Hz
- Sample quantity*
- 2 × 45 ml
- Final fineness*
- ~ 0.1 µm
AUTOMATED CRYOGENIC PREPARATION
CryoMill
Automatic cooling. More useful sample preparation.. Automatic liquid-nitrogen cooling.
- Grinding stations
- 1
- Frequency
- 5–30 Hz
- Sample quantity*
- Up to 20 mL
- Final fineness*
- ~ 5 µm
TEMPERATURE AS A PROCESS VARIABLE
MM 500 control
Monitored heating, cooling & temperature-sensitive methods. Thermal plates; external tempering device required.
- Grinding stations
- 2
- Frequency
- 3–30 Hz
- Sample quantity*
- 2 × 45 ml
- Final fineness*
- ~ 0.1 µm
*Feed size, final fineness and useful sample quantity depend on the material, tools and operating conditions. Jar volume is not the sample filling volume. The finest result and largest feed or batch are not simultaneous guarantees.
SIDE BY SIDE
Compare the method.
Then choose the mill.
| Model | Best starting point | Feed size* | Fineness* | Frequency | Stations / sample* | Temperature approach |
|---|---|---|---|---|---|---|
| MM 400 | Routine preparation & flexible small samples | ≤ 8 mm | ~ 5 µm | 3–30 Hz | 2 / 2 × 20 ml | Manual pre-cooling with compatible steel jars |
| MM 500 vario | Parallel batches & biological sample throughput | ≤ 8 mm | ~ 5 µm | 3–35 Hz | 6 / 6 × 20 ml | Manual pre-cooling with compatible steel jars |
| MM 500 nano | Ultrafine wet grinding & high-energy research | ≤ 10 mm | ~ 0.1 µm | 3–35 Hz | 2 / 2 × 45 ml | Manual pre-cooling; no integrated thermal plates |
| CryoMill | Automatic cooling. More useful sample preparation. | ≤ 8 mm | ~ 5 µm | 5–30 Hz | 1 / Up to 20 mL | Automatic liquid-nitrogen cooling |
| MM 500 control | Monitored heating, cooling & temperature-sensitive methods | ≤ 10 mm | ~ 0.1 µm | 3–30 Hz | 2 / 2 × 45 ml | Thermal plates; external tempering device required |
*Feed size, final fineness and useful sample quantity depend on the material, tools and operating conditions. Jar volume is not the sample filling volume. The finest result and largest feed or batch are not simultaneous guarantees. On smaller screens, scroll the comparison horizontally.
HOW MIXER MILLS WORK
Motion turns
into preparation.
Horizontal oscillation moves the jars rapidly back and forth. Grinding balls strike the material at the jar ends, while impact and friction reduce particles and mix the contents.
The method changes with the task: larger balls favor impact; smaller balls and beads increase contact and mixing. Wet grinding adds liquid and a suitable dispersing strategy. Compatible small-vial adapters support biological workflows.
- Dry preparation for suitable brittle or conditioned samples
- Wet grinding for suspensions and demanding ultrafine methods
- Cryogenic methods for elastic or temperature-sensitive samples
SOLID-STATE & PHARMACEUTICAL RESEARCH
Mechanochemistry.
Co-crystal screening.
Explore how the MM 400 applies mechanical energy to small-sample chemical research, from repeatable reaction conditions to solid-form screening and biomass functionalization.
Mechanochemical synthesis
Use impact-driven milling, small jars and programmable methods to investigate solid-state reactions. Calibration, loading and frequency help define a repeatable experiment.
Explore MM 400 mechanochemistryCo-crystal screening
Compare dry milling and liquid-assisted grinding in small steel tubes. Review the theophylline–benzamide example and its powder X-ray diffraction assessment.
Explore co-crystal screeningFunctional biomaterials
See a reported example of cotton-fiber functionalization and the role of milling in developing cationic cellulose for pharmaceutical research.
Explore biomass functionalizationTEMPERATURE CHANGES THE CHOICE
Three ways to approach cold grinding.
Pre-cool manually
MM 400, MM 500 vario and MM 500 nano can use suitable manually precooled steel jars. The method needs a plan for warming and any cooling pauses.
Learn moreCool automatically
CryoMill uses automatic liquid-nitrogen pre-cooling and continuous cooling during the run. Choose it when cryogenic embrittlement is the main task.
Learn moreRegulate with thermal plates
MM 500 control couples the jars to thermal plates and an external tempering source. cryoPad is required for liquid-nitrogen operation.
Learn moreMATERIALS & APPLICATIONS
Prepare for the question
you want to answer.
Analytical fineness, reliable homogenization, cell disruption or a mechanochemical reaction each calls for a different combination of jar, balls, vessel and method.
- Food & feed
- Pharmaceuticals
- Plant & biological samples
- Environmental samples
- Minerals & ceramics
- Polymers & elastomers
- Battery materials
- Mechanochemistry
Keep the sample’s identity.
Choose tool materials around the analysis. Hardened steel, stainless steel, tungsten carbide, zirconium oxide and other model-specific options have different wear and compatibility considerations.
Document the whole method.
Record sample filling, ball size and quantity, frequency, duration and temperature handling. A representative trial helps establish a repeatable preparation method.
YOUR MATERIAL. YOUR NEXT STEP.
Put the process
to the material test.
Tell us what you’re processing and what needs to change. We’ll help define the equipment, accessories and a useful trial.
- Material and starting particle size
- Target fineness and required quantity
- Temperature, purity and cleaning requirements