Make elastic samples grindable
Continuous liquid-nitrogen cooling embrittles rubber, plastics and fibrous materials so impact and friction can reduce them more effectively.
AUTOMATED CRYOGENIC PREPARATION
CryoMill.
Cold by design.
Turn elastic, fibrous and temperature-sensitive samples into grindable material with automatic liquid-nitrogen cooling before and during milling. CryoMill helps preserve volatile components and also supports dry and wet grinding at ambient temperature.
Configuration examples. Accessories may be optional.
FEED SIZE*≤ 8 mm
FINAL FINENESS*~ 5 µm
FREQUENCY5–30 Hz
SAMPLE QUANTITY*Up to 20 mL
THE MODEL IN FOCUS
Automatic cooling. More useful sample preparation.
Help retain volatile components
Cooling before and throughout milling limits warming during preparation and helps preserve volatile constituents in temperature-sensitive samples.
Automatic cooling before grinding
The automatic cycle delays milling until the required pre-cooling condition has been reached, supporting repeatable starting conditions.
Closed liquid-nitrogen supply
Autofill delivers nitrogen through a closed cooling circuit, reducing direct handling of liquid nitrogen during the automatic process.
Cooling matched to the cycle
Nitrogen is supplied as required to maintain the cryogenic cooling condition. Intermediate cooling supports longer methods and controlled nitrogen use.
Three modes in one benchtop mill
Use cryogenic grinding, or suitable dry and wet methods at ambient temperature. One compact system supports size reduction, mixing, homogenization and reaction-vial cell disruption.
HOW IT WORKS
Oscillation.
Impact. Mixing.
Grinding jars oscillate in a horizontal position. The balls’ inertia drives them into the sample at the rounded jar ends. Impact and friction reduce the material while the motion mixes it.
Match ball size, number, jar material, filling level, frequency and time to the sample. Use smaller beads for compatible bead-beating methods; use a validated liquid and dispersion method for wet grinding.
Feed size, final fineness and useful sample quantity depend on the material, tools and operating conditions. Jar volume is not the sample filling volume. The finest result and largest feed or batch are not simultaneous guarantees.
METHOD & CONFIGURATION
Continuous cooling. Consistent preparation.
The jar oscillates horizontally while grinding balls strike the sample. Liquid nitrogen circulates through the cooling system around the jar rather than being poured into the sample. Nitrogen at approximately −196 °C provides the cooling medium; actual sample conditions depend on the method and cooling cycle.
- Cooling before and during grinding; intermediate cooling for longer sequences
- Nine stored SOPs and programmable cooling/grinding cycles
- Up to 20 mL useful sample quantity; 50 mL maximum nominal jar
- Adapters for four 5 mL jars or six 2 mL reaction vials
AUTOMATION & REPEATABILITY
Keep the method consistent.
Automatic cooling, digital settings and stored methods bring recurring preparation tasks into a repeatable laboratory workflow.
Digital control and status
A clearly arranged keypad provides digital frequency, pre-cooling and grinding-time settings. Display LEDs distinguish cooling and grinding states, making the current process stage visible.
Stored methods and cycles
Nine SOP memories support recurring methods. Up to nine cooling and grinding cycles can be programmed, including intermediate cooling for longer preparations. Parameters remain available during standby.
Compact, flexible handling
A single self-centering clamping station accommodates screw-top jars and small-sample adapters. The benchtop format combines cryogenic preparation with ambient dry or wet milling.
CLOSED AUTOMATIC COOLING
Cold before the first impact.
Cooling throughout the run.
Liquid nitrogen cools the grinding jar through the integrated cooling system before and during milling. The automatic sequence first establishes the cooling condition, then maintains it during processing.
The nitrogen cooling reference is approximately -196°C. Cooling performance and actual sample conditions depend on loading, tools and the method. Intermediate cooling can be incorporated when an application needs a longer sequence.
- Automatic nitrogen delivery through a closed circuit
- Demand-based supply helps limit unnecessary nitrogen use
- Optional 50 L Autofill container or compatible external tank connection
- Ambient-temperature operation available without nitrogen cooling
The closed system reduces direct nitrogen handling during the automatic cycle. Installation, supply and laboratory cryogenic provisions remain part of the complete configuration.
APPLICATION BENEFITS
Prepare materials that resist
room-temperature grinding.
Material behavior and the downstream analysis determine the method. The listed feed range includes hard, medium-hard, soft, brittle, elastic and fibrous samples.
Polymers, rubber and fibers
Cryogenic embrittlement helps elastic and fibrous materials fracture. Examples include plastics, rubber, textiles, wool, paper and wood.
Food, plants and pharmaceuticals
Low-temperature preparation supports suitable oily seeds, feed, plant material and tablets, including samples where warming or volatile loss would affect analysis.
Biological and environmental samples
Applications include tissue, hair, bone, soil, sludge and waste. The reaction-vial adapter also supports compatible small-sample cell disruption methods.
BUILD THE RIGHT SETUP
The tools make the method.
Select jars, balls and supporting accessories around your material and analysis. Confirm the complete configuration and what is included in the quotation.
Screw-top jars, balls and adapters
One self-centering grinding station accepts 10, 25, 35 or 50 mL jars. An adapter accommodates four 5 mL jars; another holds six 2 mL reaction vials. Screw-top closures support leak-resistant processing. Nominal vessel volume differs from useful sample quantity.
Liquid-nitrogen Autofill system
An optional 50 L supply container supports approximately five hours of cryogenic grinding, depending on the method. A compatible existing cryogenic tank can be connected using the specified connection tube and safety-valve arrangement.
Materials for sample compatibility
Tool materials include hardened steel, stainless steel, zirconium oxide and PTFE. A 25 mL zirconium oxide jar with matching balls, available in a cryogenic-compatible design, provides an option where steel-related contamination matters; PTFE jars are also available. Confirm the material, jar size and grinding mode together.
MATERIALS & APPLICATIONS
Start with the sample.
- Rubber & plastics
- Textiles & wool
- Paper & wood
- Oily seeds & animal feed
- Plants & food
- Tablets & chemical products
- Tissue, hair & bone
- Soil, sludge & waste
- Mixing & homogenization
- Cell disruption in reaction vials
TECHNICAL DATA
A closer look at CryoMill.
| Grinding stations | 1 |
|---|---|
| Maximum feed size* | ≤ 8 mm |
| Final fineness* | ~ 5 µm |
| Useful sample quantity* | Up to 20 mL |
| Nominal jar volume | 5, 10, 25, 35 or 50 mL; adapters depend on format |
| Vibrational frequency | 5–30 Hz |
| Temperature approach | Automatic liquid-nitrogen cooling |
View additional technical specifications
| Feed material | hard, medium-hard, soft, brittle, elastic, fibrous |
|---|---|
| Size reduction principle | impact, friction |
| Material feed size* | <= 8 mm |
| Final fineness* | ~ 5 µm |
| Batch size / feed quantity* | max. 20 ml |
| No. of grinding stations | 1 |
| Vibrational frequency | digital, 5 – 30 Hz (300 – 1800 min-1) |
| Typical mean grinding time | 10 min / 4 min (cooling / grinding) |
| Dry grinding | yes |
| Wet grinding | yes |
| Cryogenic grinding | yes |
| Cell disruption with reaction vials | yes |
| Self-centering clamping device | yes |
| Type of grinding jars | screw top design |
| Material of grinding tools | hardened steel, stainless steel, zirconium oxide, PTFE |
| Grinding jar sizes | 5 ml / 10ml / 25 ml / 35 ml / 50 ml |
| Autofill | 50 l |
| Setting of grinding time | digital, 30 s – 99 min |
| Storable SOPs | 9 |
| Electrical supply data | 100-240 V, 50/60 Hz |
| Power connection | 1-phase |
| Protection code | IP 30 |
| Power consumption | 260 W |
| W x H x D closed | 395 x 373 x 577 mm (D: 710 mm with exhaust tube) |
| Net weight | ~ 45 kg |
| Standards | CE |
*Feed size, final fineness and useful sample quantity depend on the material, tools and operating conditions. Jar volume is not the sample filling volume. The finest result and largest feed or batch are not simultaneous guarantees.
EXPLORE THE FAMILY
A different priority?
MM 400
Routine preparation & flexible small samples
MM 500 vario
Parallel batches & biological sample throughput
MM 500 nano
Ultrafine wet grinding & high-energy research
MM 500 control
Monitored heating, cooling & temperature-sensitive methods
YOUR MATERIAL. YOUR NEXT STEP.
Put the process
to the material test.
Tell us what you’re processing and what needs to change. We’ll help define the equipment, accessories and a useful trial.
- Material and starting particle size
- Target fineness and required quantity
- Temperature, purity and cleaning requirements