Cell Disruption

Bead/Ball Mill – These mills use small grinding media to act against cells by one of two methods. The DYNO®-MILL and BeadBeater series use agitator discs inside an enclosed chamber to whip the beads into a high-shear frenzy which then collide with the cells and produce breakage. The other mills listed here use a violent shaking action (either side-to-side or up-and-down) to bring about rapid cell disruption.

Rotor-Stator Homogenizers
– This type of homogenizer employs a high speed, tightly fitted rotor inside a many toothed stator. The samples to be homogenized are drawn into the center of the rotor having been mixed, accelerated and pressed through the narrow gap between the rotor and stator. The Polytron and Tissue Tearor units are batch models and the Megatron is continuous.

Ultrasonic Liquid Processor
– High frequency oscillations of a piezoelectric crystal are translated into very small movements of a submerged probe. As the probe moves in it “pushes” the sample away, as it moves in a void is created which collapses and creates localized cavitation. This cavitation causes rapid homogenization of many types of cells. The Sonicator is a batch model and the Sonitube is continuous.

High Pressure Homogenizer
– Both these units utilize high pressure to burst cell walls. The French Press G-M™ uses a hydraulic press and carefully machined pressure cells to produce pressures up to 40,000 psi. The MicroMincer is a small hand operated unit.